About Gene List

PF3D7_1457400

Genome location: Pf3D7_14_v3:2,349,282..2,360,424(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.96 0.59
Trophozoite not expressed 0.89 0.55
Schizont possibly expressed 0.57 0.70
Gametocyte possibly expressed 0.84 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.874 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1321100)

Modification: Other | RMgm-432

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533628

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 187 96 212
disruptive 104 624 346 750
missense 92 585 328 669

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 52 334 159 255
disruptive 261 1287 510 973
missense 196 1149 441 712

PlasmoDB Total SNPs: 443

Non-coding: 111 | Synonymous: 172 | Nonsynonymous: 159 | Stop Codon: 1

Protein Information

Protein Length: 3055 | Molecular Weight (kDa): 371.014

UniProt ID(s): Q8IKQ6

PDB ID(s): None

Isoelectric Point: 9.19

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104