PF3D7_1457600

Genome location: Pf3D7_14_v3:2,363,337..2,365,373(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.38	0.82
Trophozoite	not expressed	0.69	0.62
Schizont	not expressed	0.42	0.73
Gametocyte	not expressed	0.52	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.217 | MFS: -2.778 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1321300)

Relative Growth Rate: 0.08 ± 0.09
Confidence: 6.21

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKQ4

"Best" AlphaFill ligand hit: U2F (uridine-5'-diphosphate-2-deoxy-2-fluoro-alpha-d-glucose, Local RMSD=18.20) with 7MSK (Global RMSD=21.63)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532529

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	37	18	46
disruptive	22	80	62	136
missense	20	79	59	119

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	74	24	56
disruptive	41	229	102	232
missense	31	195	91	159

PlasmoDB Total SNPs: 67

Non-coding: 20 | Synonymous: 24 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 553 | Molecular Weight (kDa): 66.309

UniProt ID(s): Q8IKQ4

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A