About Gene List

PF3D7_1457700

Genome location: Pf3D7_14_v3:2,366,520..2,372,154(+)

Genome classification: Core

Function and Localization

Product Description: large ribosomal subunit nuclear export factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.54 0.37
Trophozoite expressed 0.98 0.52
Schizont possibly expressed 0.28 0.84
Gametocyte not expressed 0.69 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457700

Resistome Missense Mutations: K882Q

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.109 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKQ3

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.06) with 5NBD (Global RMSD=26.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532770

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 23 87 57 111
disruptive 67 279 136 342
missense 36 200 113 278

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 37 188 76 102
disruptive 145 594 247 503
missense 66 448 191 315

PlasmoDB Total SNPs: 266

Non-coding: 108 | Synonymous: 90 | Nonsynonymous: 68 | Stop Codon: 0

Protein Information

Protein Length: 1478 | Molecular Weight (kDa): 177.666

UniProt ID(s): Q8IKQ3

PDB ID(s): None

Isoelectric Point: 9.12

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005612 CCAAT-binding factor
PFam PF03914 CCAAT-binding factor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097