PF3D7_1457700

Genome location: Pf3D7_14_v3:2,366,520..2,372,154(+)

Genome classification: Core

Function and Localization

Product Description: large ribosomal subunit nuclear export factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.54	0.37
Trophozoite	expressed	0.98	0.52
Schizont	possibly expressed	0.28	0.84
Gametocyte	not expressed	0.69	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457700

Resistome Missense Mutations: K882Q

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.109 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKQ3

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.06) with 5NBD (Global RMSD=26.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532770

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	23	87	57	111
disruptive	67	279	136	342
missense	36	200	113	278

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	188	76	102
disruptive	145	594	247	503
missense	66	448	191	315

PlasmoDB Total SNPs: 266

Non-coding: 108 | Synonymous: 90 | Nonsynonymous: 68 | Stop Codon: 0

Protein Information

Protein Length: 1478 | Molecular Weight (kDa): 177.666

UniProt ID(s): Q8IKQ3

PDB ID(s): None

Isoelectric Point: 9.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005612	CCAAT-binding factor
PFam	PF03914	CCAAT-binding factor
Superfamily	N/A	N/A