PF3D7_1457800

Genome location: Pf3D7_14_v3:2,372,222..2,374,557(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.12	0.92
Schizont	not expressed	0.10	0.93
Gametocyte	expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.717 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKQ2

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=4.74) with 7K3Z (Global RMSD=47.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533049

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	36	17	34
disruptive	40	136	65	143
missense	28	112	59	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	56	30	43
disruptive	72	270	89	194
missense	47	217	68	128

PlasmoDB Total SNPs: 126

Non-coding: 44 | Synonymous: 50 | Nonsynonymous: 31 | Stop Codon: 1

Protein Information

Protein Length: 503 | Molecular Weight (kDa): 60.108

UniProt ID(s): Q8IKQ2

PDB ID(s): None

Isoelectric Point: 4.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A