PF3D7_1457900

Genome location: Pf3D7_14_v3:2,375,197..2,386,669(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.78	0.66
Trophozoite	expressed	1.60	0.33
Schizont	expressed	1.65	0.39
Gametocyte	expressed	1.15	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.955 | MFS: -2.91 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533712

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	38	190	123	281
disruptive	111	771	460	875
missense	87	727	430	800

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	65	392	175	310
disruptive	256	1520	629	1117
missense	184	1358	550	837

PlasmoDB Total SNPs: 453

Non-coding: 48 | Synonymous: 199 | Nonsynonymous: 203 | Stop Codon: 3

Protein Information

Protein Length: 3455 | Molecular Weight (kDa): 419.397

UniProt ID(s): Q8IKQ1

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A