Genome location: Pf3D7_14_v3:2,390,249..2,390,902(+)
Genome classification: Core
Product Description: protein PET117, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.32 | 0.84 |
| Trophozoite | not expressed | 0.32 | 0.79 |
| Schizont | possibly expressed | 0.24 | 0.84 |
| Gametocyte | possibly expressed | 0.37 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1458100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKQ0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106323
Most Similar Human Ortholog: Q6UWS5
TM-align score: 0.84 | RMSD: 1.33
Seq Identity: 0.07 | Length: 58 / 58
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000232838 | PET117 cytochrome c oxidase chaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 1 | 4 |
| disruptive | 0 | 2 | 3 | 10 |
| missense | 0 | 2 | 2 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 2 | 9 |
| disruptive | 4 | 6 | 6 | 17 |
| missense | 1 | 5 | 5 | 10 |
PlasmoDB Total SNPs: 38
Non-coding: 36 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 58 | Molecular Weight (kDa): 6.896
UniProt ID(s): Q8IKQ0
PDB ID(s): None
Isoelectric Point: 10.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR031568 | Protein Pet117, mitochondrial |
| PFam | PF15786 | Protein Pet117, mitochondrial |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 8381337 | Sequence and chromosomal localization of two PET genes required for cytochrome coxidase assembly in Saccharomyces cerevisiae | McEwen JE, Hong KH, Park S, Preciado GT | 10.1007/BF00336742 |