Genome location: Pf3D7_14_v3:2,399,870..2,405,556(+)
Genome classification: Core
Product Description: spindle assembly abnormal protein 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | not expressed | 0.67 | 0.64 |
| Schizont | not expressed | 0.52 | 0.71 |
| Gametocyte | not expressed | 0.64 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1458500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.613 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1322200)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1322200)
Modification: Tagged | RMgm-5365
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKP6
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=35.80) with 6JWQ (Global RMSD=49.69)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105142
Most Similar Human Ortholog: Q9HC77
TM-align score: 0.21 | RMSD: 9.54
Seq Identity: 0.08 | Length: 413 / 1469
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151849 | centromere protein J |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 107 | 69 | 107 |
| disruptive | 58 | 307 | 190 | 422 |
| missense | 39 | 273 | 172 | 360 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 44 | 199 | 78 | 119 |
| disruptive | 144 | 705 | 310 | 558 |
| missense | 92 | 596 | 261 | 385 |
PlasmoDB Total SNPs: 250
Non-coding: 65 | Synonymous: 95 | Nonsynonymous: 88 | Stop Codon: 2
Protein Length: 1469 | Molecular Weight (kDa): 174.109
UniProt ID(s): Q8IKP6
PDB ID(s): None
Isoelectric Point: 5.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34014972 | Dynamics of SAS-I mediated H4 K16 acetylation during DNA replication in yeast | Boltengagen M, Samel-Pommerencke A, Fechtig D, Ehrenhofer-Murray AE | 10.1371/journal.pone.0251660 |
| 35550346 | Plasmodium SAS4: basal body component of male cell which is dispensable forparasite transmission | Zeeshan M, Brady D, ..., Tewari R | 10.26508/lsa.202101329 |
| 35077503 | Expansion microscopy of Plasmodium gametocytes reveals the molecular architectureof a bipartite microtubule organisation centre coordinating mitosis with axonemeassembly | Rashpa R, Brochet M | 10.1371/journal.ppat.1010223 |