PF3D7_1458600

Genome location: Pf3D7_14_v3:2,406,002..2,410,561(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.54	0.74
Trophozoite	expressed	0.44	0.74
Schizont	expressed	0.20	0.87
Gametocyte	possibly expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1458600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -2.952 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1322300)

Relative Growth Rate: 0.03 ± 0.21
Confidence: 4.48

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKP5

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.05) with 3UM6 (Global RMSD=28.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532422

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	69	42	85
disruptive	34	209	98	291
missense	33	204	94	272

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	133	68	102
disruptive	88	453	209	385
missense	71	414	183	273

PlasmoDB Total SNPs: 201

Non-coding: 90 | Synonymous: 65 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 1163 | Molecular Weight (kDa): 139.589

UniProt ID(s): Q8IKP5

PDB ID(s): None

Isoelectric Point: 6.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013087	Zinc finger C2H2-type
PFam	N/A	N/A
Superfamily	N/A	N/A