Product Description: exonuclease V, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.11.5 (Exodeoxyribonuclease V)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0045145 | single-stranded DNA 5'-3' exodeoxyribonuclease activity |
| Process | GO:0036297 | interstrand cross-link repair |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.12 | 0.92 |
| Schizont | expressed | 0.15 | 0.89 |
| Gametocyte | expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1458700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.173 | MFS: -3.097 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1322400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1322400)
Modification: Disrupted | RMgm-3514
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKP4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.11.5 | exodeoxyribonuclease V | ATPd(GCTGGTGG)d(GCAGGTGG)abc proteinGamma-proteinbacteriophage Mud(GATTAGGCTGGTGG)d(GATTAGGCaGGTGG)d(TAGGCTGGTGGGAT)d(TAGGCaGGTGGGAT)d(GCTGGTGGgattag)d(GCAGGTGGGATTAG)... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106506
Most Similar Human Ortholog: Q9H790
TM-align score: 0.78 | RMSD: 2.46
Seq Identity: 0.23 | Length: 302 / 353
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164002 | exonuclease 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 233
Non-coding: 214 | Synonymous: 16 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 353 | Molecular Weight (kDa): 42.068
UniProt ID(s): Q8IKP4
PDB ID(s): None
Isoelectric Point: 6.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019190 | Exonuclease V |
| PFam | PF09810 | Exonuclease V |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |