PF3D7_1458800

Genome location: Pf3D7_14_v3:2,414,388..2,418,536(-)

Genome classification: Core

Function and Localization

Product Description: DNA-directed RNA polymerase III subunit RPC5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005666	RNA polymerase III complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.88
Trophozoite	possibly expressed	0.24	0.85
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1458800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKP3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102756

Most Similar Human Ortholog: H3BNJ0

TM-align score: 0.72 | RMSD: 2.43

Seq Identity: 0.25 | Length: 77 / 865

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000058600	RNA polymerase III subunit E
ENSG00000284282	RNA polymerase III subunit E

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	47	25	64
disruptive	40	139	89	180
missense	27	114	69	145

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	109	37	74
disruptive	76	301	165	316
missense	51	243	123	178

PlasmoDB Total SNPs: 238

Non-coding: 126 | Synonymous: 64 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 865 | Molecular Weight (kDa): 103.366

UniProt ID(s): Q8IKP3

PDB ID(s): None

Isoelectric Point: 5.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006886	DNA-directed RNA polymerase III subunit Rpc5
PFam	PF04801	DNA-directed RNA polymerase III subunit Rpc5
Superfamily	N/A	N/A