Genome location: Pf3D7_14_v3:2,418,138..2,419,436(+)
Genome classification: Core
Product Description: golgi apparatus membrane protein TVP23, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030173 | integral component of Golgi membrane |
| Process | GO:0009306 | protein secretion |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.07 | 0.95 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.02 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1458900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.198 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKP2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101456
Most Similar Human Ortholog: K7ENL4
TM-align score: 0.83 | RMSD: 2.29
Seq Identity: 0.26 | Length: 126 / 230
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166676 | trans-golgi network vesicle protein 23 homolog A |
| ENSG00000171928 | trans-golgi network vesicle protein 23 homolog B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 9 | 11 |
| disruptive | 2 | 30 | 20 | 57 |
| missense | 2 | 29 | 20 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 26 | 12 | 17 |
| disruptive | 6 | 81 | 35 | 84 |
| missense | 4 | 69 | 26 | 60 |
PlasmoDB Total SNPs: 30
Non-coding: 23 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 230 | Molecular Weight (kDa): 27.666
UniProt ID(s): Q8IKP2
PDB ID(s): None
Isoelectric Point: 7.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008564 | Golgi apparatus membrane protein TVP23-like |
| PFam | PF05832 | Golgi apparatus membrane protein TVP23-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16107716 | Immunoisolaton of the yeast Golgi subcompartments and characterization of a novelmembrane protein, Svp26, discovered in the Sed5-containing compartments | Inadome H, Noda Y, Adachi H, Yoda K | 10.1128/MCB.25.17.7696-7710.2005 |
| 17178117 | Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containingGolgi/endosome compartments of Saccharomyces cerevisiae | Inadome H, Noda Y, ..., Yoda K | 10.1016/j.yexcr.2006.11.008 |
| 19076069 | TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrogradetransport from the early endosome to the late Golgi | Stein IS, Gottfried A, Zimmermann J, Fischer von Mollard G | 10.1042/BJ20081973 |