PF3D7_1459100

Genome location: Pf3D7_14_v3:2,423,624..2,426,573(+)

Genome classification: Core

Function and Localization

Product Description: GTP-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	expressed	0.13	0.92
Schizont	possibly expressed	0.03	0.98
Gametocyte	not expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1459100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.112 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1322800)

Relative Growth Rate: 0.25 ± 0.29
Confidence: 3.86

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKP0

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=1.33) with 3EC1 (Global RMSD=5.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102331

Most Similar Human Ortholog: Q8NC60

TM-align score: 0.49 | RMSD: 3.67

Seq Identity: 0.22 | Length: 376 / 797

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000084092	nitric oxide associated 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	41	27	72
disruptive	16	106	74	163
missense	10	98	60	136

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	92	45	74
disruptive	44	238	113	252
missense	27	192	88	189

PlasmoDB Total SNPs: 124

Non-coding: 55 | Synonymous: 43 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 797 | Molecular Weight (kDa): 94.095

UniProt ID(s): Q8IKP0

PDB ID(s): None

Isoelectric Point: 9.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006073	GTP binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF01926	GTP binding domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094