PF3D7_1459200

Genome location: Pf3D7_14_v3:2,426,855..2,430,865(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.13	0.51
Trophozoite	expressed	0.60	0.66
Schizont	expressed	0.32	0.79
Gametocyte	expressed	0.48	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1459200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 7 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.114 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKN9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533096

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	56	29	74
disruptive	41	175	81	224
missense	25	153	68	186

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	115	40	85
disruptive	82	377	144	345
missense	49	300	117	218

PlasmoDB Total SNPs: 211

Non-coding: 109 | Synonymous: 45 | Nonsynonymous: 54 | Stop Codon: 3

Protein Information

Protein Length: 955 | Molecular Weight (kDa): 113.232

UniProt ID(s): Q8IKN9

PDB ID(s): None

Isoelectric Point: 5.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily