Product Description: OPA3-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0019216 | regulation of lipid metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.94 |
| Trophozoite | not expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.26 | 0.83 |
| Gametocyte | not expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1459300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.936 | MFS: -2.228 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKN8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103296
Most Similar Human Ortholog: Q9H6K4
TM-align score: 0.70 | RMSD: 2.14
Seq Identity: 0.25 | Length: 138 / 189
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125741 | outer mitochondrial membrane lipid metabolism regulator OPA3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 5 | 26 |
| disruptive | 2 | 6 | 3 | 31 |
| missense | 1 | 6 | 3 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 11 | 19 |
| disruptive | 4 | 30 | 27 | 65 |
| missense | 1 | 25 | 20 | 27 |
PlasmoDB Total SNPs: 94
Non-coding: 80 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 189 | Molecular Weight (kDa): 22.248
UniProt ID(s): Q8IKN8
PDB ID(s): None
Isoelectric Point: 10.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010754 | Optic atrophy 3-like |
| PFam | PF07047 | Optic atrophy 3-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |