PF3D7_1459400

Genome location: Pf3D7_14_v3:2,432,882..2,435,344(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003723	RNA binding
Process	GO:0044409	entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.18	0.90
Trophozoite	expressed	0.39	0.76
Schizont	expressed	0.49	0.71
Gametocyte	possibly expressed	0.24	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1459400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.143 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKN7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142794

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	22	16	23
disruptive	6	16	16	45
missense	6	16	15	39

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	56	8	27
disruptive	12	67	34	99
missense	9	52	25	57

PlasmoDB Total SNPs: 108

Non-coding: 90 | Synonymous: 15 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 340 | Molecular Weight (kDa): 40.069

UniProt ID(s): Q8IKN7

PDB ID(s): None

Isoelectric Point: 10.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
33019810	Localization and function of a Plasmodium falciparum protein (PF3D7_1459400)during erythrocyte invasion.	Amlabu E, Nyarko PB, ..., Awandare GA	10.1177/1535370220961764
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21