PF3D7_1459600

Genome location: Pf3D7_14_v3:2,440,293..2,444,201(+)

Genome classification: Core

Function and Localization

Product Description: AP-4 complex accessory subunit Tepsin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.31	0.85
Trophozoite	expressed	0.35	0.79
Schizont	expressed	0.25	0.83
Gametocyte	expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1459600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.002 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1323200)

Relative Growth Rate: 0.96 ± 0.12
Confidence: 5.58

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1323200)

Modification: Disrupted | RMgm-3517

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKN5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138217

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	52	26	49
disruptive	35	101	73	149
missense	21	85	71	138

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	86	34	54
disruptive	56	214	115	219
missense	34	188	104	183

PlasmoDB Total SNPs: 235

Non-coding: 169 | Synonymous: 28 | Nonsynonymous: 36 | Stop Codon: 2

Protein Information

Protein Length: 801 | Molecular Weight (kDa): 93.594

UniProt ID(s): Q8IKN5

PDB ID(s): None

Isoelectric Point: 9.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008942	ENTH/VHS
InterPro	IPR039273	AP-4 complex accessory subunit Tepsin
PFam	N/A	N/A
Superfamily	SSF48464	ENTH/VHS

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108