Product Description: bax inhibitor 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.89 |
| Trophozoite | expressed | 0.72 | 0.59 |
| Schizont | expressed | 0.32 | 0.79 |
| Gametocyte | expressed | 1.30 | 0.38 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1459800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.256 | MFS: -2.62 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKN3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103839
Most Similar Human Ortholog: F8W1V3
TM-align score: 0.91 | RMSD: 1.72
Seq Identity: 0.35 | Length: 196 / 243
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000139644 | transmembrane BAX inhibitor motif containing 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 18 | 9 | 19 |
| disruptive | 0 | 4 | 8 | 28 |
| missense | 0 | 4 | 7 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 35 | 9 | 18 |
| disruptive | 2 | 26 | 24 | 50 |
| missense | 0 | 18 | 21 | 36 |
PlasmoDB Total SNPs: 106
Non-coding: 82 | Synonymous: 21 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 243 | Molecular Weight (kDa): 27.896
UniProt ID(s): Q8IKN3
PDB ID(s): None
Isoelectric Point: 9.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006214 | Bax inhibitor 1-related |
| PFam | PF01027 | Bax inhibitor 1-related |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29269729 | A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii. | Long S, Anthony B, Drewry LL, Sibley LD | 10.1038/s41467-017-02341-2 |