Product Description: rhoptry protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0020008 | rhoptry |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1459900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.183 | MFS: -2.982 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKN2
"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=23.11) with 4XYD (Global RMSD=25.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 7 | 12 | 19 |
| disruptive | 2 | 11 | 11 | 29 |
| missense | 2 | 10 | 10 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 34 | 13 | 15 |
| disruptive | 2 | 35 | 30 | 40 |
| missense | 2 | 26 | 25 | 34 |
PlasmoDB Total SNPs: 58
Non-coding: 48 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 193 | Molecular Weight (kDa): 23.055
UniProt ID(s): Q8IKN2
PDB ID(s): None
Isoelectric Point: 8.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 24841368 | Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. | Butler CL, Lucas O, ..., White M | 10.1371/journal.pone.0097625 |