Genome location: Pf3D7_14_v3:2,454,639..2,456,200(+)
Genome classification: Core
Product Description: FYVE and coiled-coil domain-containing protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.83 | 0.62 |
| Trophozoite | possibly expressed | 0.28 | 0.84 |
| Schizont | not expressed | 0.15 | 0.91 |
| Gametocyte | possibly expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1460100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.047 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKN0
"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=0.11) with 3IED (Global RMSD=47.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 22 | 8 | 32 |
| disruptive | 5 | 19 | 15 | 43 |
| missense | 5 | 18 | 15 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 41 | 14 | 24 |
| disruptive | 11 | 63 | 32 | 80 |
| missense | 9 | 49 | 26 | 52 |
PlasmoDB Total SNPs: 56
Non-coding: 43 | Synonymous: 5 | Nonsynonymous: 7 | Stop Codon: 1
Protein Length: 325 | Molecular Weight (kDa): 37.68
UniProt ID(s): Q8IKN0
PDB ID(s): None
Isoelectric Point: 5.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000306 | FYVE zinc finger |
| InterPro | IPR011011 | Zinc finger, FYVE/PHD-type |
| PFam | PF01363 | FYVE zinc finger |
| Superfamily | SSF57903 | Zinc finger, FYVE/PHD-type |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17289673 | Traffic to the malaria parasite food vacuole: a novel pathway involving aphosphatidylinositol 3-phosphate-binding protein. | McIntosh MT, Vaid A, ..., Sharma P | 10.1074/jbc.M610974200 |