Genome location: Pf3D7_14_v3:2,459,048..2,460,369(-)
Genome classification: Core
Product Description: 60S ribosomal protein L29, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.04 | 0.55 |
| Trophozoite | no data | 1.48 | 0.34 |
| Schizont | no data | 0.25 | 0.84 |
| Gametocyte | no data | 0.68 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1460300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.399 | MFS: -0.06 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1324000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1324000)
Modification: Disrupted | RMgm-3521
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3J6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101591
Most Similar Human Ortholog: P47914
TM-align score: 0.77 | RMSD: 1.48
Seq Identity: 0.56 | Length: 57 / 67
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000162244 | ribosomal protein L29 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 73
Non-coding: 71 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 67 | Molecular Weight (kDa): 8.014
UniProt ID(s): C6S3J6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002673 | Ribosomal protein L29e |
| PFam | PF01779 | Ribosomal protein L29e |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |