Genome location: Pf3D7_14_v3:2,473,732..2,475,410(+)
Genome classification: Core
Product Description: inner membrane complex sub-compartment protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.95 |
| Trophozoite | not expressed | 0.12 | 0.92 |
| Schizont | expressed | 0.83 | 0.59 |
| Gametocyte | expressed | 0.33 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1460600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.567 | MFS: -2.264 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1328100)
Modification: Tagged | RMgm-4895
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKM6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 92
Non-coding: 86 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 148 | Molecular Weight (kDa): 17.117
UniProt ID(s): Q8IKM6
PDB ID(s): None
Isoelectric Point: 5.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR041316 | ISP1 C-terminal |
| PFam | PF18161 | ISP1 C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 22389454 | Evolution and architecture of the inner membrane complex in asexual and sexualstages of the malaria parasite. | Kono M, Herrmann S, ..., Gilberger TW | 10.1093/molbev/mss081 |
| 24244852 | Unique apicomplexan IMC sub-compartment proteins are early markers for apicalpolarity in the malaria parasite. | Poulin B, Patzewitz EM, ..., Tewari R | 10.1242/bio.20136163 |
| 32395856 | A protein palmitoylation cascade regulates microtubule cytoskeleton integrity inPlasmodium | Wang X, Qian P, ..., Yuan J | 10.15252/embj.2019104168 |
| 36650056 | Protein S-palmitoylation regulates different stages of meiosis inSchizosaccharomyces pombe | Pham TV, Hsiao WY, ..., Wang SW | 10.26508/lsa.202201755 |
| 7954893 | Identification and characterization of genes induced during sexualdifferentiation in Schizosaccharomyces pombe | Sato S, Suzuki H, ..., Tabata S | 10.1007/BF00326301 |
| 33202882 | The Fission Yeast RNA-Binding Protein Meu5 Is Involved in Outer ForesporeMembrane Breakdown during Spore Formation | Zhang B, Teraguchi E, ..., Nakamura T | 10.3390/jof6040284 |
| 24623719 | The fission yeast spore is coated by a proteinaceous surface layer comprisingmainly Isp3 | Fukunishi K, Miyakubi K, ..., Nakamura T | 10.1091/mbc.E13-12-0731 |
| 33375328 | Quick-Freeze, Deep-Etch Electron Microscopy Reveals the CharacteristicArchitecture of the Fission Yeast Spore | Tahara YO, Miyata M, Nakamura T | 10.3390/jof7010007 |
| 20844581 | A novel family of Toxoplasma IMC proteins displays a hierarchical organizationand functions in coordinating parasite division | Beck JR, Rodriguez-Fernandez IA, ..., Bradley PJ | 10.1371/journal.ppat.1001094 |