Genome location: Pf3D7_14_v3:2,477,828..2,479,750(-)
Genome classification: Core
Product Description: snRNA-activating protein complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0019185 | snRNA-activating protein complex |
| Function | GO:0001006 | RNA polymerase III type 3 promoter sequence-specific DNA binding |
| Function | GO:0003681 | bent DNA binding |
| Process | GO:0042795 | snRNA transcription by RNA polymerase II |
| Process | GO:0042796 | snRNA transcription by RNA polymerase III |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.07 | 0.95 |
| Gametocyte | not expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1460800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -2.874 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKM4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103413
Most Similar Human Ortholog: Q5T284
TM-align score: 0.79 | RMSD: 1.42
Seq Identity: 0.23 | Length: 108 / 635
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164975 | small nuclear RNA activating complex polypeptide 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 36 | 20 | 50 |
| disruptive | 18 | 68 | 46 | 106 |
| missense | 11 | 50 | 35 | 84 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 79 | 30 | 47 |
| disruptive | 35 | 189 | 94 | 179 |
| missense | 19 | 126 | 63 | 111 |
PlasmoDB Total SNPs: 78
Non-coding: 2 | Synonymous: 41 | Nonsynonymous: 35 | Stop Codon: 0
Protein Length: 635 | Molecular Weight (kDa): 75.928
UniProt ID(s): Q8IKM4
PDB ID(s): None
Isoelectric Point: 7.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022042 | snRNA-activating protein complex, subunit 3 |
| PFam | PF12251 | snRNA-activating protein complex, subunit 3 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 14757834 | The Trypanosoma brucei spliced leader RNA and rRNA gene promoters haveinterchangeable TbSNAP50-binding elements | Schimanski B, Laufer G, Gontcharova L, Gunzl A | 10.1093/nar/gkh231 |