Genome location: Pf3D7_14_v3:2,480,089..2,482,257(+)
Genome classification: Core
Product Description: ribosomal protein S10, apicoplast, putative
SignalP Peptide: MNVVIYIFSFLTLYNICSS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1460900.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.238 | MFS: -2.754 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKM3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100367
Most Similar Human Ortholog: P60866
TM-align score: 0.74 | RMSD: 2.92
Seq Identity: 0.19 | Length: 107 / 268
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000008988 | ribosomal protein S20 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 14 | 14 | 18 |
| disruptive | 3 | 10 | 15 | 38 |
| missense | 3 | 10 | 14 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 28 | 21 | 29 |
| disruptive | 6 | 46 | 22 | 63 |
| missense | 3 | 36 | 16 | 47 |
PlasmoDB Total SNPs: 157
Non-coding: 142 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 268 | Molecular Weight (kDa): 32.585
UniProt ID(s): A0A1S6WN11, A0A1S6WN72, Q8IKM3
PDB ID(s): None
Isoelectric Point: 10.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001848 | Ribosomal protein S10 |
| InterPro | IPR027486 | Ribosomal protein S10 domain |
| InterPro | IPR036838 | Ribosomal protein S10 domain superfamily |
| PFam | PF00338 | Ribosomal protein S10 domain |
| Superfamily | SSF54999 | Ribosomal protein S10 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31609965 | Genetic mapping of fitness determinants across the malaria parasite Plasmodiumfalciparum life cycle | Li X, Kumar S, ..., Vaughan AM | 10.1371/journal.pgen.1008453 |
| 36303209 | Apicoplast ribosomal protein S10-V127M enhances artemisinin resistance of aKelch13 transgenic Plasmodium falciparum | Kampoun T, Srichairatanakool S, ..., Uthaipibull C | 10.1186/s12936-022-04330-3 |
| 35511795 | Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations inPlasmodium falciparum parasite population in Uganda | Ocan M, Ashaba FK, ..., Nsobya SL | 10.1371/journal.pone.0268095 |
| 25599401 | Genetic architecture of artemisinin-resistant Plasmodium falciparum | Miotto O, Amato R, ..., Kwiatkowski DP | 10.1038/ng.3189 |