PF3D7_1461000

Genome location: Pf3D7_14_v3:2,482,286..2,485,604(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	expressed	0.69	0.62
Schizont	expressed	0.15	0.91
Gametocyte	expressed	1.06	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.17 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1324700)

Relative Growth Rate: 0.69 ± 0.33
Confidence: 3.59

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1324700)

Modification: Disrupted | RMgm-3523

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKM2

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=4.76) with 3IED (Global RMSD=19.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532836

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	21	12	22
disruptive	17	39	22	81
missense	10	28	11	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	39	17	36
disruptive	30	108	55	135
missense	18	68	42	79

PlasmoDB Total SNPs: 221

Non-coding: 140 | Synonymous: 54 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 495 | Molecular Weight (kDa): 59.36

UniProt ID(s): Q8IKM2

PDB ID(s): None

Isoelectric Point: 5.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003021	Rad1/Rec1/Rad17
PFam	PF02144	Rad1/Rec1/Rad17
Superfamily	SSF55979	N/A