PF3D7_1461200 (IMP3)

Genome location: Pf3D7_14_v3:2,489,191..2,490,622(+)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar ribonucleoprotein protein IMP3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034457	Mpp10 complex
Component	GO:0032040	small-subunit processome
Function	GO:0030515	snoRNA binding
Process	GO:0006364	rRNA processing
Process	GO:0042274	ribosomal small subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.05	0.97
Schizont	possibly expressed	0.01	1.00
Gametocyte	expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.91 | MFS: -2.448 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A2N8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102070

Most Similar Human Ortholog: Q9NV31

TM-align score: 0.97 | RMSD: 0.74

Seq Identity: 0.45 | Length: 182 / 183

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000177971	IMP U3 small nucleolar ribonucleoprotein 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	7	7
disruptive	1	7	3	18
missense	1	7	3	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	12	9	5
disruptive	2	15	16	32
missense	2	14	14	19

PlasmoDB Total SNPs: 39

Non-coding: 36 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 183 | Molecular Weight (kDa): 22.024

UniProt ID(s): A0A144A2N8

PDB ID(s): None

Isoelectric Point: 10.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001912	Ribosomal protein S4/S9, N-terminal
InterPro	IPR002942	RNA-binding S4 domain
InterPro	IPR022801	Ribosomal protein S4/S9
PFam	PF00163	Ribosomal protein S4/S9, N-terminal
PFam	PF01479	RNA-binding S4 domain
Superfamily	SSF55174	N/A