About Gene List

PF3D7_1461300

Genome location: Pf3D7_14_v3:2,491,624..2,493,185(+)

Genome classification: Core

Function and Localization

Product Description: 40S ribosomal protein S28e, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022627 cytosolic small ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003735 structural constituent of ribosome
Process GO:0030490 maturation of SSU-rRNA
Process GO:0000028 ribosomal small subunit assembly
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.73 0.30
Trophozoite expressed 1.83 0.24
Schizont expressed 0.76 0.56
Gametocyte expressed 1.68 0.24

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.122 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKL9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101185

Most Similar Human Ortholog: P62857

TM-align score: 0.89 | RMSD: 0.81

Seq Identity: 0.68 | Length: 63 / 67

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000233927 ribosomal protein S28

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 101

Non-coding: 100 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 67 | Molecular Weight (kDa): 7.494

UniProt ID(s): Q8IKL9

PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP

Isoelectric Point: 11.48

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000289 Ribosomal protein S28e
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR028626 Ribosomal protein S28e conserved site
PFam PF01200 Ribosomal protein S28e
Superfamily SSF50249 Nucleic acid-binding, OB-fold

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596