PF3D7_1461400

Genome location: Pf3D7_14_v3:2,493,244..2,495,035(-)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.08	0.95
Schizont	expressed	0.89	0.57
Gametocyte	expressed	0.88	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.359 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKL8

"Best" AlphaFill ligand hit: ACI (6-amino-4-hydroxymethyl-cyclohex-4-ene-1,2,3-triol, Local RMSD=1.07) with 1UA7 (Global RMSD=11.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145964

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	15	19
disruptive	2	4	5	21
missense	2	4	5	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	32	17	21
disruptive	3	24	15	70
missense	3	17	13	49

PlasmoDB Total SNPs: 67

Non-coding: 51 | Synonymous: 14 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 322 | Molecular Weight (kDa): 36.96

UniProt ID(s): Q8IKL8

PDB ID(s): None

Isoelectric Point: 7.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
PFam	PF02493	MORN motif
Superfamily	SSF82185	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
34956931	Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum.	Hou N, Li S, ..., Chen Q	https://pubmed.ncbi.nlm.nih.gov/34956931/