Genome location: Pf3D7_14_v3:2,496,050..2,497,400(-)
Genome classification: Core
Product Description: meiotic nuclear division protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0003690 | double-stranded DNA binding |
| Process | GO:0007131 | reciprocal meiotic recombination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.00 | 1.00 |
| Trophozoite | no data | 0.00 | 1.00 |
| Schizont | no data | nd | 1.00 |
| Gametocyte | no data | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1461500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.148 | MFS: -2.634 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3J7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103073
Most Similar Human Ortholog: D6RCT6
TM-align score: 0.64 | RMSD: 3.32
Seq Identity: 0.17 | Length: 96 / 204
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000121211 | meiotic nuclear divisions 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 6 | 13 |
| disruptive | 1 | 18 | 9 | 21 |
| missense | 1 | 17 | 8 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 7 | 19 |
| disruptive | 5 | 31 | 19 | 35 |
| missense | 1 | 26 | 18 | 29 |
PlasmoDB Total SNPs: 36
Non-coding: 33 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 204 | Molecular Weight (kDa): 24.382
UniProt ID(s): C6S3J7
PDB ID(s): None
Isoelectric Point: 9.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005647 | Meiotic nuclear division protein 1 |
| InterPro | IPR040453 | Mnd1, HTH domain |
| PFam | PF03962 | Mnd1, HTH domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37272974 | Differential expression of meiosis and homologous recombination-related genes inthe life cycle of Trypanosoma cruzi | Cruz-Saavedra L, Caceres T, ..., Ramirez JD | 10.1007/s00436-023-07850-2 |