PF3D7_1461700

Genome location: Pf3D7_14_v3:2,500,927..2,502,802(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNVLKLVLLFPLIMLLTHNIKIQS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.04	0.97
Schizont	no data	0.03	0.98
Gametocyte	no data	1.56	0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.141 | MFS: -2.983 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533681

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	3	8
disruptive	0	14	6	13
missense	0	14	5	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	10	10	7
disruptive	1	35	16	27
missense	1	29	13	19

PlasmoDB Total SNPs: 145

Non-coding: 132 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 126 | Molecular Weight (kDa): 15.262

UniProt ID(s): C6S3J8

PDB ID(s): None

Isoelectric Point: 11.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A