PF3D7_1461800

Genome location: Pf3D7_14_v3:2,503,209..2,514,031(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.12	0.94
Schizont	not expressed	0.10	0.95
Gametocyte	expressed	1.73	0.27

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1461800

Resistome Missense Mutations: N608D

Resistome Compounds with Missense Mutations: MMV668399

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.968 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105253

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	25	150	91	174
disruptive	120	540	293	639
missense	86	456	254	534

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	48	293	135	181
disruptive	227	1073	416	855
missense	156	899	346	601

PlasmoDB Total SNPs: 756

Non-coding: 186 | Synonymous: 343 | Nonsynonymous: 227 | Stop Codon: 0

Protein Information

Protein Length: 2739 | Molecular Weight (kDa): 324.897

UniProt ID(s): A0A144A533

PDB ID(s): None

Isoelectric Point: 6.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104