PF3D7_1462100

Genome location: Pf3D7_14_v3:2,519,132..2,523,362(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.69	0.62
Schizont	expressed	0.36	0.78
Gametocyte	not expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1462100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.112 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKL3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533177

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	62	41	105
disruptive	42	164	112	263
missense	33	135	101	220

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	135	62	103
disruptive	82	423	184	371
missense	54	325	153	264

PlasmoDB Total SNPs: 117

Non-coding: 19 | Synonymous: 55 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1334 | Molecular Weight (kDa): 161.198

UniProt ID(s): Q8IKL3

PDB ID(s): None

Isoelectric Point: 8.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A