PF3D7_1462300

Genome location: Pf3D7_14_v3:2,524,283..2,529,768(-)

Genome classification: Core

Function and Localization

Product Description: GTP-binding protein, putative

SignalP Peptide: MNKLFFLCFLVIIIYSLS

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.23	0.48
Trophozoite	expressed	1.17	0.42
Schizont	expressed	0.51	0.71
Gametocyte	not expressed	0.63	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1462300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -3.307 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKL1

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.42) with 3Q5E (Global RMSD=13.44)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117799

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	68	46	126
disruptive	23	95	76	148
missense	21	91	69	117

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	162	58	116
disruptive	41	253	96	277
missense	32	213	80	191

PlasmoDB Total SNPs: 144

Non-coding: 55 | Synonymous: 62 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 1357 | Molecular Weight (kDa): 161.219

UniProt ID(s): Q8IKL1

PDB ID(s): None

Isoelectric Point: 6.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR015894	Guanylate-binding protein, N-terminal
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF02263	Guanylate-binding protein, N-terminal
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21