PF3D7_1462400

Genome location: Pf3D7_14_v3:2,531,297..2,544,021(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	2.04	0.28
Trophozoite	not expressed	0.74	0.62
Schizont	not expressed	0.35	0.82
Gametocyte	not expressed	0.80	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1462400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 9 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.226 | #Insertions: 21

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533313

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	174	107	198
disruptive	144	712	328	760
missense	118	613	280	640

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	61	354	137	225
disruptive	276	1343	539	1025
missense	212	1096	450	723

PlasmoDB Total SNPs: 687

Non-coding: 283 | Synonymous: 219 | Nonsynonymous: 185 | Stop Codon: 0

Protein Information

Protein Length: 3322 | Molecular Weight (kDa): 395.678

UniProt ID(s): Q8IKL0

PDB ID(s): None

Isoelectric Point: 6.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104