PF3D7_1462500

Genome location: Pf3D7_14_v3:2,544,824..2,549,785(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Function	GO:0008017	microtubule binding
Process	GO:0051493	regulation of cytoskeleton organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.43	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1462500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.957 | MFS: -2.519 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1326100)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.25

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1326100)

Modification: Disrupted | RMgm-3526

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKK9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105954

Most Similar Human Ortholog: Q8NEY3

TM-align score: 0.42 | RMSD: 5.42

Seq Identity: 0.20 | Length: 193 / 762

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000150628	spermatogenesis associated 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	49	24	57
disruptive	11	93	53	120
missense	9	89	52	114

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	87	33	57
disruptive	23	189	93	172
missense	21	170	89	124

PlasmoDB Total SNPs: 291

Non-coding: 254 | Synonymous: 19 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 762 | Molecular Weight (kDa): 91.86

UniProt ID(s): Q8IKK9

PDB ID(s): None

Isoelectric Point: 7.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010441	CH-like domain in sperm protein
PFam	PF06294	CH-like domain in sperm protein
Superfamily	N/A	N/A