Genome location: Pf3D7_14_v3:2,553,386..2,555,456(-)
Genome classification: Core
Product Description: cytochrome c1, heme protein, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0009055 | electron transfer activity |
| Function | GO:0045153 | electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity |
| Process | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.48 | 0.71 |
| Schizont | expressed | 0.29 | 0.81 |
| Gametocyte | expressed | 0.58 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1462700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.158 | MFS: -2.857 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1326300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6U9
"Best" AlphaFill ligand hit: 6PE (1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine, Local RMSD=0.05) with 5OKD (Global RMSD=1.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102032
Most Similar Human Ortholog: P08574
TM-align score: 0.71 | RMSD: 1.74
Seq Identity: 0.49 | Length: 244 / 394
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000179091 | cytochrome c1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 8 | 16 |
| disruptive | 1 | 8 | 12 | 25 |
| missense | 1 | 7 | 12 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 22 | 8 | 20 |
| disruptive | 4 | 19 | 24 | 60 |
| missense | 3 | 17 | 23 | 46 |
PlasmoDB Total SNPs: 59
Non-coding: 47 | Synonymous: 8 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 394 | Molecular Weight (kDa): 46.187
UniProt ID(s): Q8I6U9
PDB ID(s): None
Isoelectric Point: 8.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002326 | Cytochrome c1 |
| InterPro | IPR021157 | Cytochrome c1, transmembrane anchor, C-terminal |
| InterPro | IPR036909 | Cytochrome c-like domain superfamily |
| PFam | PF02167 | Cytochrome c1 |
| Superfamily | SSF46626 | Cytochrome c-like domain superfamily |
| Superfamily | SSF81496 | Cytochrome c1, transmembrane anchor, C-terminal |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 31622418 | Effects of MCHM on yeast metabolism | Pupo A, Ku KM, Gallagher JEG | 10.1371/journal.pone.0223909 |
| 36791950 | Delving into the molecular initiating event of cadmium toxification via thedose-dependent functional genomics approach in Saccharomyces cerevisiae | Guan M, Wang X, ..., Zhang X | 10.1016/j.envpol.2023.121287 |