PF3D7_1462900

Genome location: Pf3D7_14_v3:2,560,998..2,563,920(-)

Genome classification: Core

Function and Localization

Product Description: AAA ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.19	0.91
Trophozoite	not expressed	0.25	0.84
Schizont	not expressed	0.04	0.98
Gametocyte	not expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1462900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.001 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKK6

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.43) with 2QOR (Global RMSD=19.84)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533636

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	43	33	51
disruptive	38	175	112	194
missense	27	165	103	176

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	82	46	47
disruptive	72	363	120	241
missense	51	326	103	184

PlasmoDB Total SNPs: 109

Non-coding: 29 | Synonymous: 39 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 807 | Molecular Weight (kDa): 97.669

UniProt ID(s): Q8IKK6

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00004	ATPase, AAA-type, core
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase