About Gene List

PF3D7_1463500

Genome location: Pf3D7_14_v3:2,576,989..2,580,007(+)

Genome classification: Core

Function and Localization

Product Description: fam-a protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0008525 phosphatidylcholine transporter activity
Process GO:0015914 phospholipid transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.19 0.91
Trophozoite possibly expressed 0.07 0.95
Schizont possibly expressed 0.04 0.97
Gametocyte possibly expressed 0.14 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1463500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.837 | MFS: -2.865 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1101000)

  • Relative Growth Rate: 1.10 ± 0.14
  • Confidence: 5.31

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKK1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100943

Most Similar Human Ortholog: C9JQC9

TM-align score: 0.42 | RMSD: 4.31

Seq Identity: 0.08 | Length: 90 / 258

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000074855 anoctamin 8
ENSG00000160746 anoctamin 10

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 20 13 23
disruptive 2 3 8 27
missense 2 3 8 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 45 15 16
disruptive 4 22 21 54
missense 3 17 18 37

PlasmoDB Total SNPs: 178

Non-coding: 163 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 258 | Molecular Weight (kDa): 30.347

UniProt ID(s): Q8IKK1

PDB ID(s): None

Isoelectric Point: 7.24

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006486 Plasmodium yoelii subtelomeric PYST-A
PFam N/A N/A
Superfamily SSF55961 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27851824 Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene FamiliesAre Expressed in Liver Stages Where They Are Exported into the ParasitophorousVacuole. Fougere A, Jackson AP, ..., Franke-Fayard B 10.1371/journal.ppat.1005917