Genome location: Pf3D7_14_v3:2,581,273..2,582,816(+)
Genome classification: Core
Product Description: cyclin 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0005675 | transcription factor TFIIH holo complex |
| Component | GO:0070985 | transcription factor TFIIK complex |
| Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| Function | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0000281 | mitotic cytokinesis |
| Process | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain |
| Process | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| Process | GO:0010564 | regulation of cell cycle process |
| Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Process | GO:0031952 | regulation of protein autophosphorylati |
| Process | GO:0006357 |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.24 | 0.88 |
| Trophozoite | expressed | 0.38 | 0.77 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1463700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.003 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKK0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102792
Most Similar Human Ortholog: P51946
TM-align score: 0.77 | RMSD: 2.80
Seq Identity: 0.18 | Length: 283 / 326
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134480 | cyclin H |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 18 | 8 | 26 |
| disruptive | 1 | 27 | 22 | 51 |
| missense | 1 | 26 | 21 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 39 | 20 | 21 |
| disruptive | 5 | 70 | 35 | 88 |
| missense | 3 | 59 | 29 | 65 |
PlasmoDB Total SNPs: 115
Non-coding: 84 | Synonymous: 25 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 326 | Molecular Weight (kDa): 39.233
PDB ID(s): None
Isoelectric Point: 8.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006671 | Cyclin, N-terminal |
| InterPro | IPR013763 | Cyclin-like |
| InterPro | IPR036915 | Cyclin-like superfamily |
| InterPro | IPR043198 | Cyclin/Cyclin-like subunit Ssn8 |
| PFam | PF00134 | Cyclin, N-terminal |
| Superfamily | SSF47954 | Cyclin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10722743 | Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 andcyclin H. Functional characterization of a P. falciparum cyclin homologue. | Le Roch K, Sestier C, ..., Doerig C | 10.1074/jbc.275.12.8952 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20332005 | The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replicationproteins and co-localize in the nucleus. | Jirage D, Chen Y, ..., Waters NC | https://pubmed.ncbi.nlm.nih.gov/20332005/ |
| 28611247 | The Malaria Parasite Cyclin H Homolog Pf Cyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum | Robbins JA, Absalon S, Streva VA, Dvorin JD | 10.1128/mBio.00605-17 |
| 37014634 | PhiReX 2.0: A Programmable and Red Light-Regulated CRISPR-dCas9 System for theActivation of Endogenous Genes in Saccharomyces cerevisiae | Machens F, Ran G, ..., Hochrein L | 10.1021/acssynbio.2c00517 |
| 37380138 | RNAseq analysis of mutants in coding and non-coding transcription of phosphategenes in the yeast Saccharomyces cerevisiae | van Heusden GPH | 10.1016/j.ygeno.2023.110672 |
| 38112096 | The presence of a G-quadruplex prone sequence upstream of a minimal promoterincreases transcriptional activity in the yeast Saccharomyces cerevisiae | Kratochvilova L, Vojsovic M, ..., Brazda V | 10.1042/BSR20231348 |