Product Description: ribosomal protein S6, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0070181 | small ribosomal subunit rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | possibly expressed | 0.01 | 1.00 |
| Gametocyte | possibly expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1463800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.248 | MFS: -2.382 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKJ9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 5 | 10 |
| disruptive | 0 | 3 | 2 | 13 |
| missense | 0 | 3 | 2 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 8 | 12 |
| disruptive | 0 | 11 | 12 | 28 |
| missense | 0 | 8 | 9 | 16 |
PlasmoDB Total SNPs: 22
Non-coding: 18 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 120 | Molecular Weight (kDa): 14.39
UniProt ID(s): Q8IKJ9
PDB ID(s): None
Isoelectric Point: 10.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000529 | Ribosomal protein S6 |
| InterPro | IPR020814 | Ribosomal protein S6, plastid/chloroplast |
| InterPro | IPR035980 | Ribosomal protein S6 superfamily |
| PFam | PF01250 | Ribosomal protein S6 |
| Superfamily | SSF54995 | Ribosomal protein S6 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |