Product Description: YL1 nuclear protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Process | GO:0043486 | histone exchange |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.71 | 0.67 |
| Trophozoite | possibly expressed | 0.60 | 0.66 |
| Schizont | possibly expressed | 0.35 | 0.78 |
| Gametocyte | not expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1464000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.155 | MFS: -2.911 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1327400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKJ7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104390
Most Similar Human Ortholog: Q15906
TM-align score: 0.20 | RMSD: 6.96
Seq Identity: 0.09 | Length: 119 / 705
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163159 | vacuolar protein sorting 72 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 33 | 30 | 48 |
| disruptive | 11 | 90 | 59 | 146 |
| missense | 10 | 82 | 53 | 123 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 78 | 38 | 62 |
| disruptive | 32 | 234 | 103 | 210 |
| missense | 20 | 195 | 83 | 151 |
PlasmoDB Total SNPs: 72
Non-coding: 29 | Synonymous: 25 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 705 | Molecular Weight (kDa): 84.613
UniProt ID(s): Q8IKJ7
PDB ID(s): None
Isoelectric Point: 4.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008895 | Vps72/YL1 family |
| InterPro | IPR013272 | Vps72/YL1, C-terminal |
| PFam | PF05764 | Vps72/YL1 family |
| PFam | PF08265 | Vps72/YL1, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |