PF3D7_1464400

Genome location: Pf3D7_14_v3:2,603,892..2,606,282(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.19	0.90
Trophozoite	possibly expressed	0.26	0.84
Schizont	expressed	0.12	0.92
Gametocyte	not expressed	0.07	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1464400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.894 | MFS: -2.018 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKJ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103042

Most Similar Human Ortholog: O00488

TM-align score: 0.70 | RMSD: 2.96

Seq Identity: 0.28 | Length: 99 / 104

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000142684	zinc finger protein 593

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	1	0
missense	0	0	0	0

PlasmoDB Total SNPs: 128

Non-coding: 123 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 104 | Molecular Weight (kDa): 12.466

UniProt ID(s): Q8IKJ3

PDB ID(s): None

Isoelectric Point: 10.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger
InterPro	IPR013087	Zinc finger C2H2-type
InterPro	IPR022755	Zinc finger, double-stranded RNA binding
InterPro	IPR036236	Zinc finger C2H2 superfamily
PFam	PF12171	Zinc finger, double-stranded RNA binding
Superfamily	SSF57667	Zinc finger C2H2 superfamily