Product Description: ATP synthase (C/AC39) subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0005765 | lysosomal membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0016471 | vacuolar proton-transporting V-type ATPase complex |
| Component | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain |
| Function | GO:0008553 | P-type proton-exporting transporter activity |
| Function | GO:0046961 | proton-transporting ATPase activity, rotational mechanism |
| Process | GO:0007035 | vacuolar acidification |
| Process | GO:0007034 | vacuolar transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.14 | 0.92 |
| Trophozoite | possibly expressed | 0.20 | 0.87 |
| Schizont | possibly expressed | 0.24 | 0.83 |
| Gametocyte | not expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1464700
Resistome Missense Mutations: L260I
Resistome Compounds with Missense Mutations: MMV688533
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.121 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1328100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKJ0
"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.08) with 2BVM (Global RMSD=13.40)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101546
Most Similar Human Ortholog: P61421
TM-align score: 0.95 | RMSD: 1.56
Seq Identity: 0.42 | Length: 348 / 382
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147614 | ATPase H+ transporting V0 subunit d2 |
| ENSG00000159720 | ATPase H+ transporting V0 subunit d1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 22 | 20 | 23 |
| disruptive | 3 | 6 | 14 | 17 |
| missense | 3 | 6 | 14 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 56 | 10 | 19 |
| disruptive | 4 | 30 | 12 | 37 |
| missense | 4 | 23 | 12 | 26 |
PlasmoDB Total SNPs: 76
Non-coding: 68 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 382 | Molecular Weight (kDa): 44.532
UniProt ID(s): Q8IKJ0
PDB ID(s): None
Isoelectric Point: 4.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002843 | ATPase, V0 complex, c/d subunit |
| InterPro | IPR016727 | ATPase, V0 complex, subunit d |
| InterPro | IPR036079 | V-type ATP synthase subunit C-like |
| PFam | PF01992 | ATPase, V0 complex, c/d subunit |
| Superfamily | SSF103486 | V-type ATP synthase subunit C-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |