PF3D7_1464800

Genome location: Pf3D7_14_v3:2,628,882..2,629,789(+)

Genome classification: Core

Function and Localization

Product Description: EF-hand calcium-binding domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1464800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.234 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105180

Most Similar Human Ortholog: A0A2R8YDC4

TM-align score: 0.71 | RMSD: 2.22

Seq Identity: 0.11 | Length: 63 / 119

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000185055	EF-hand calcium binding domain 10

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	5	2
disruptive	3	15	11	16
missense	3	15	11	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	11	3	3
disruptive	4	25	13	29
missense	4	25	13	22

PlasmoDB Total SNPs: 61

Non-coding: 53 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 119 | Molecular Weight (kDa): 14.227

UniProt ID(s): C6S3K0

PDB ID(s): None

Isoelectric Point: 4.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039879	EF-hand calcium-binding domain-containing protein 10
PFam	N/A	N/A
Superfamily	N/A	N/A