Product Description: ATP-dependent zinc metalloprotease FTSH, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.24.- (Metalloendopeptidases.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0004176 | ATP-dependent peptidase activity |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.34 | 0.83 |
| Trophozoite | expressed | 0.44 | 0.74 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.24 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1464900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.156 | MFS: -2.788 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKI9
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.08) with 5C18 (Global RMSD=2.03)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.24.- | Ex: meprin A | GSHSDSATPADPNEMDTTPTXTNFEDTAEGTAPMSFPCMB... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101196
Most Similar Human Ortholog: Q96TA2
TM-align score: 0.66 | RMSD: 2.78
Seq Identity: 0.45 | Length: 497 / 706
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136758 | YME1 like 1 ATPase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 40 | 24 | 41 |
| disruptive | 3 | 33 | 15 | 58 |
| missense | 3 | 32 | 15 | 45 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 95 | 13 | 32 |
| disruptive | 8 | 79 | 36 | 104 |
| missense | 8 | 65 | 31 | 73 |
PlasmoDB Total SNPs: 148
Non-coding: 119 | Synonymous: 22 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 706 | Molecular Weight (kDa): 79.815
UniProt ID(s): Q8IKI9
PDB ID(s): None
Isoelectric Point: 9.28
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000642 | Peptidase M41 |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR003959 | ATPase, AAA-type, core |
| InterPro | IPR003960 | ATPase, AAA-type, conserved site |
| InterPro | IPR005936 | Peptidase, FtsH |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR037219 | Peptidase M41-like |
| PFam | PF00004 | ATPase, AAA-type, core |
| PFam | PF01434 | Peptidase M41 |
| Superfamily | SSF140990 | Peptidase M41-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24058559 | An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum. | Tanveer A, Allen SM, ..., Habib S | 10.1371/journal.pone.0074408 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |