Genome location: Pf3D7_14_v3:2,635,372..2,637,005(+)
Genome classification: Core
Product Description: cytochrome c oxidase subunit 6A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0006119 | oxidative phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.93 |
| Schizont | expressed | 0.20 | 0.85 |
| Gametocyte | expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1465000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.703 | MFS: -2.154 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1328400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKI8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 15 | 9 | 8 |
| disruptive | 6 | 15 | 19 | 35 |
| missense | 5 | 15 | 19 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 24 | 10 | 12 |
| disruptive | 9 | 44 | 27 | 67 |
| missense | 8 | 40 | 22 | 52 |
PlasmoDB Total SNPs: 57
Non-coding: 47 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 278 | Molecular Weight (kDa): 33.254
UniProt ID(s): Q8IKI8
PDB ID(s): None
Isoelectric Point: 10
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 26759378 | The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediatesdegradation of nuclear-encoded complex IV subunits | Cesnekova J, Rodinova M, ..., Stiburek L | 10.1042/BJ20151029 |