Genome location: Pf3D7_14_v3:2,637,018..2,640,318(+)
Genome classification: Core
Product Description: conserved oligomeric Golgi complex subunit 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0017119 | Golgi transport complex |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | not expressed | 0.48 | 0.72 |
| Schizont | possibly expressed | 0.40 | 0.76 |
| Gametocyte | not expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1465100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.898 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKI7
"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.62) with 2Q8Z (Global RMSD=18.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102906
Most Similar Human Ortholog: Q9Y2V7
TM-align score: 0.61 | RMSD: 4.83
Seq Identity: 0.12 | Length: 489 / 867
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000133103 | component of oligomeric golgi complex 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 50 | 22 | 64 |
| disruptive | 28 | 116 | 82 | 126 |
| missense | 27 | 115 | 82 | 123 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 87 | 41 | 68 |
| disruptive | 40 | 247 | 106 | 193 |
| missense | 36 | 235 | 103 | 144 |
PlasmoDB Total SNPs: 102
Non-coding: 45 | Synonymous: 25 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 867 | Molecular Weight (kDa): 104.896
UniProt ID(s): Q8IKI7
PDB ID(s): None
Isoelectric Point: 6.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010490 | Conserved oligomeric Golgi complex subunit 6 |
| PFam | PF06419 | Conserved oligomeric Golgi complex subunit 6 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 36519157 | Investigation the global effect of rare earth gadolinium on the buddingSaccharomyces cerevisiae by genome-scale screening | Cao Y, Zhang C, ..., Wang X | 10.3389/fmicb.2022.1022054 |