About Gene List

PF3D7_1465400

Genome location: Pf3D7_14_v3:2,646,364..2,648,126(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.17 0.91
Trophozoite expressed 0.07 0.96
Schizont expressed 0.06 0.95
Gametocyte expressed 0.12 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1465400

Resistome Missense Mutations: V31F

Resistome Compounds with Missense Mutations: MMV006901

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.241 | MFS: -3.341 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1328800)

  • Relative Growth Rate: 0.14 ± 0.08
  • Confidence: 6.55

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKI4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179360

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 1
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 1 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 69

Non-coding: 68 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 90 | Molecular Weight (kDa): 11.009

UniProt ID(s): Q8IKI4

PDB ID(s): None

Isoelectric Point: 10.72

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g