PF3D7_1465600

Genome location: Pf3D7_14_v3:2,655,491..2,657,965(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.32	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1465600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.327 | MFS: -2.506 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1329000)

Relative Growth Rate: 1.04 ± 0.15
Confidence: 5.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1329000)

Modification: Disrupted | RMgm-3543

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKI1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532643

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	25	17	33
disruptive	16	49	31	67
missense	15	47	31	62

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	48	29	37
disruptive	23	97	49	101
missense	22	88	40	78

PlasmoDB Total SNPs: 143

Non-coding: 120 | Synonymous: 10 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 485 | Molecular Weight (kDa): 56.819

UniProt ID(s): Q2KNY1, Q2KNY2, Q2KNY3, Q8IKI1

PDB ID(s): None

Isoelectric Point: 6.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A