Product Description: 40S ribosomal protein S3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.59 | 0.38 |
| Trophozoite | expressed | 1.83 | 0.24 |
| Schizont | expressed | 0.39 | 0.76 |
| Gametocyte | expressed | 1.24 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1465900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.205 | MFS: -3.469 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKH8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100514
Most Similar Human Ortholog: F2Z2S8
TM-align score: 0.96 | RMSD: 1.10
Seq Identity: 0.76 | Length: 117 / 221
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000149273 | ribosomal protein S3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 4 | 11 |
| disruptive | 0 | 0 | 0 | 6 |
| missense | 0 | 0 | 0 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 5 | 15 |
| disruptive | 0 | 6 | 3 | 31 |
| missense | 0 | 4 | 2 | 19 |
PlasmoDB Total SNPs: 103
Non-coding: 90 | Synonymous: 11 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 221 | Molecular Weight (kDa): 24.668
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001351 | Ribosomal protein S3, C-terminal |
| InterPro | IPR004044 | K Homology domain, type 2 |
| InterPro | IPR005703 | Ribosomal protein S3, eukaryotic/archaeal |
| InterPro | IPR009019 | K homology domain superfamily, prokaryotic type |
| InterPro | IPR036419 | Ribosomal protein S3, C-terminal domain superfamily |
| PFam | PF00189 | Ribosomal protein S3, C-terminal |
| PFam | PF07650 | K Homology domain, type 2 |
| Superfamily | SSF54814 | K homology domain superfamily, prokaryotic type |
| Superfamily | SSF54821 | Ribosomal protein S3, C-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |