PF3D7_1466000

Genome location: Pf3D7_14_v3:2,686,224..2,688,303(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKTYINLFFLLSLLKVTFIYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.23	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1466000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.98 | MFS: -2.48 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1329400)

Relative Growth Rate: 1.06 ± 0.17
Confidence: 4.98

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1329400)

Modification: Disrupted | RMgm-3545

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKH6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158488

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	14	18
disruptive	2	26	17	39
missense	2	26	17	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	37	16	22
disruptive	6	63	24	64
missense	4	58	23	50

PlasmoDB Total SNPs: 90

Non-coding: 72 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 313 | Molecular Weight (kDa): 36.535

UniProt ID(s): Q8IKH6

PDB ID(s): None

Isoelectric Point: 8.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A